کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1681470 | 1518648 | 2016 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
سطوح، پوششها و فیلمها
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چکیده انگلیسی
Gold nanoparticles have been reported as a possible radio-sensitizer agent in radiation therapy due to their ability to increase energy deposition and subsequent direct damage to cells and DNA within their local vicinity. Moreover, this increase in energy deposition also results in an increase of the radiochemical yields. In this work we present, for the first time, an in silico investigation, based on the general purpose Monte Carlo simulation toolkit Geant4, into energy deposition and radical species production around a spherical gold nanoparticle 50Â nm in diameter via proton irradiation. Simulations were preformed for incident proton energies ranging from 2 to 170Â MeV, which are of interest for clinical proton therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms - Volume 373, 15 April 2016, Pages 126-139
Journal: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms - Volume 373, 15 April 2016, Pages 126-139
نویسندگان
H.N. Tran, M. Karamitros, V.N. Ivanchenko, S. Guatelli, S. McKinnon, K. Murakami, T. Sasaki, S. Okada, M.C. Bordage, Z. Francis, Z. El Bitar, M.A. Bernal, J.I. Shin, S.B. Lee, Ph. Barberet, T.T. Tran, J.M.C. Brown, T.V. Nhan Hao, S. Incerti,