A concise and simple click reaction catalyzed by immobilized Cu(I) in an ionic liquid leading to the synthesis of β-hydroxy triazoles

This study describes an ecocompatible, concise, and practically reliable approach for the regioselective synthesis of β-hydroxy triazoles via Huisgen's click coupling reaction among varied epoxides, NaN3, and suitable acetylenes catalysed by immobilized Cu(I) in ionic liquid (IL). This one-pot, atom-economic, efficient, and highly regioselective green protocol ensures higher yield of β-hydroxy triazole scaffolds (85–95%). To make the process ecofriendly, this study emphasizes on the catalyst immobilization technique along with its possible recycling that gave a high reaction yield in up to three runs. The structures of all synthesized compounds have been characterized by comparing 1H nuclear magnetic resonance (NMR), 13C NMR, and mass spectroscopic data with those reported in the literature.