Deep eutectic solvent-assisted one-pot synthesis of 2-aminothiazole and 2-aminoxazole derivatives

• A catalyst-free multicomponent reaction in DES is explored.
• Lost-cost, wide-scope and highly efficient substituted 2-aminothiazole and 2-aminoxazole were prepared.
• The method uses ecofriendly, green and efficient DES as a catalyst as well as a solvent.
• This protocol eliminates the use of hazardous organic solvents and toxic catalysts.

Choline chloride–urea-based deep eutectic solvent (DES) has been found to be a highly effective catalyst and reaction medium for the one-pot synthesis of 2-aminothiazole and 2-aminoxazole derivatives. Three-component reactions of active methylene compounds, urea or thiourea and N-bromosuccinimide NBS in deep eutectic solvent furnished structurally diverse 2-aminoxazoles and 2-aminothiazoles in good to excellent yields under mild reaction conditions and short reaction times. DES is inexpensive, biodegradable and more accessible in any laboratory and industry.

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