کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1759065 | 1019262 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro sonodynamic cytotoxicity in regulated cavitation conditions
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
آکوستیک و فرا صوت
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In vitro sonodynamic cytotoxicity in regulated cavitation conditions In vitro sonodynamic cytotoxicity in regulated cavitation conditions](/preview/png/1759065.png)
چکیده انگلیسی
Sonodynamic toxicity has always been linked to the cavitation phenomenon. In this work, sonodynamic effect with Photofrin® was evaluated with a new ultrasound device: a regulated cavitation generator. In this way, acoustic intensity was substituted with cavitation level as ultrasound parameter. Photofrin® potentiated significantly the cavitation cytotoxicity even for low setpoints where no inertial cavitation appeared. Therefore sonodynamic mechanism was principally mechanical, facilitated by the Photofrin® insertion in cellular cytoplasmic membranes. This assertion was also supported by the fact that sonodynamic cytotoxicity was independent from the Photofrin® presence or absence in the extracellular medium. Reproducible sonodynamic efficiency was perfectly obtained with this new regulated cavitation generator.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasonics - Volume 49, Issue 2, February 2009, Pages 238-243
Journal: Ultrasonics - Volume 49, Issue 2, February 2009, Pages 238-243
نویسندگان
Jhony El Maalouf, Jean-Christophe Béra, Laurent Alberti, Dominique Cathignol, Jean-Louis Mestas,