Sonoporation, anti-cancer drug and antibody delivery using ultrasound

It has been shown experimentally in cell suspensions that sonoporation could be used to deliver the anti-cancer drug Adriamycin hydrochloride (ADR) into Jurkat lymphocytes and that it could also be used to deliver goat anti-rabbit IgG and anti-mouse IgD, antibodies into human peripheral blood mononuclear cells (PBMC) and Jurkat lymphocytes. When ADR was delivered, the delivery efficiency reached 4.80 ± 2.04% and control baseline (no ultrasound and no ADR) was 0.17 ± 0.14%. When anti-rabbit IgD was delivered, the efficiencies were 34.90 ± 1.80% (control baseline was 1.33 ± 0.31%) and 32.50 ± 4.36% (control baseline was 1.66 ± 0.06%) respectively for Jurkat cells and PBMC. When goat anti-rabbit IgG was delivered, the efficiencies were 78.60 ± 3.60% (control baseline was 1.60 ± 0.00%) and 57.50 ± 4.23% (control baseline was 11.30 ± 0.81%) respectively for Jurkat cells and PBMC.