کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1768719 | 1020235 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Radiation-induced cell inactivation as a cause for cancer promotion
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موضوعات مرتبط
مهندسی و علوم پایه
علوم زمین و سیارات
علوم فضا و نجوم
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چکیده انگلیسی
In space research, estimates of health risks from high-LET radiation, as well as from mixed fields are needed. Features of several applications of the biologically based two step clonal expansion (TSCE) model on data with high-LET radiation, normally α-particles from radon and from Thorotrast, are reviewed. One conclusion is that radiation might not only influence the initiating event in carcinogenesis, but may also act as a promoter. A possible mechanism which gives a promoting action from cell inactivation is presented for the organs “lung”, with a two-dimensional arrangement of the cells at risk, and for “liver” where the sensitive cells are distributed in all three dimensions. Inferences for dose-response curves at low doses and dose rates are drawn. For liver, the number and size of premalignant clones is estimated from the cancer data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advances in Space Research - Volume 37, Issue 9, 2006, Pages 1804-1808
Journal: Advances in Space Research - Volume 37, Issue 9, 2006, Pages 1804-1808
نویسندگان
W.F. Heidenreich, H.G. Paretzke,