Facile electrochemical approach for the effective detection of guanine

An electrochemical sensor for the sensitive determination of guanine has been developed, which is based on the electrodeposition of a nanostructured platinum thin film on a glassy carbon electrode. The effects of the electrodeposition time of the platinum thin film, pH, square-wave frequency and electroactive interferents on the voltammetric response of the sensor were evaluated. The optimized sensor exhibited excellent performance for the detection of guanine with a high sensitivity (157.8 nA μM− 1), a low detection limit (3.1 × 10− 8 M), a wide linear range (0.1–500 μM), as well as good reproducibility, stability, and selectivity.

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► Nanostructured Pt thin film on GCE exhibited fast electron transfer rate.
► New Pt/GCE electrochemical sensor designed for the determination of guanine.
► High analytical performance with low detection limit and high sensitivity.
► The designed guanine sensor has promising biomedical and clinical applications.