Application of polyhydroxylated fullerene derivatives in hemoglobin biosensors with enhanced antioxidant capacity

Hemoglobin (Hb) biosensors based on polyhydroxylated fullerene derivatives were constructed through layer-by-layer assembly. Not only could fullerene derivatives provide a favorable microenvironment to realize the direct electrochemistry and electrocatalysis of Hb, but they could reduce the oxidant damage for Hb caused by the attack of H2O2 as well. Moreover, the antioxidant effect was closely related with fullerene species.

► Water-soluble fullerenes have been successfully used in electrochemical Hb biosensors.
► The antioxidant properties of biosensors have been enhanced due to the ROS scavenger ability of fullerene derivatives.
► The antioxidant effect is closely related with fullerene species.