کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1832362 1027517 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preliminary assessment of the imaging capability of the YAP–(S)PET small animal scanner in neuroscience
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم ابزار دقیق
پیش نمایش صفحه اول مقاله
Preliminary assessment of the imaging capability of the YAP–(S)PET small animal scanner in neuroscience
چکیده انگلیسی

The new and fully engineered version of the YAP–(S)PET small animal scanner has been tested at the University of Mainz for preliminary assessment of its imaging capability for studies related to neuropharmacology and psychiatry. The main feature of the scanner is the capability to combine PET and SPECT techniques. It allows the development of new and interesting protocols for the investigation of many biological phenomena, more effectively than with PET or SPECT modalities alone. The scanner is made up of four detector heads, each one composed of a 4×4 cm2 of YAlO3:Ce (or YAP:Ce) matrix, and has a field of view (FOV) of 4 cm axially×4 cm ∅ transaxially. In PET mode, the volume resolution is less than 8 mm3 and is nearly constant over the whole FOV, while the sensitivity is about 2%. The SPECT performance is not so good, due to the presence of the multi-hole lead collimator in front of each head. Nevertheless, the YAP–PET scanner offers excellent resolution and sensitivity for performing on the availability of D2-like dopamine receptors on mice and rats in both PET and SPECT modalities.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment - Volume 569, Issue 2, 20 December 2006, Pages 488–491
نویسندگان
, , , , , , , , , , , ,