کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1856073 1529853 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Photo-synthesis of protein-based nanoparticles and the application in drug delivery
ترجمه فارسی عنوان
عکس سنتز نانوذرات مبتنی بر پروتئین و کاربرد آن در تحویل دارو
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک و نجوم (عمومی)
چکیده انگلیسی

Recently, protein-based nanoparticles as drug delivery systems have attracted great interests due to the excellent behavior of high biocompatibility and biodegradability, and low toxicity. However, the synthesis techniques are generally costly, chemical reagents introduced, and especially present difficulties in producing homogeneous monodispersed nanoparticles. Here, we introduce a novel physical method to synthesize protein nanoparticles which can be accomplished under physiological condition only through ultraviolet (UV) illumination. By accurately adjusting the intensity and illumination time of UV light, disulfide bonds in proteins can be selectively reduced and the subsequent self-assembly process can be well controlled. Importantly, the co-assembly can also be dominated when the proteins mixed with either anti-cancer drugs, siRNA, or active targeting molecules. Both in vitro and in vivo experiments indicate that our synthesized protein–drug nanoparticles (drug-loading content and encapsulation efficiency being ca. 8.2% and 70%, respectively) not only possess the capability of traditional drug delivery systems (DDS), but also have a greater drug delivery efficiency to the tumor sites and a better inhibition of tumor growth (only 35% of volume comparing to the natural growing state), indicating it being a novel drug delivery system in tumor therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Physics - Volume 358, July 2015, Pages 225–235
نویسندگان
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