کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1875677 1532090 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Studies on batch formulation of a kit for the preparation of the 99mTc-Ubiquicidin (29-41): An infection imaging agent
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
Studies on batch formulation of a kit for the preparation of the 99mTc-Ubiquicidin (29-41): An infection imaging agent
چکیده انگلیسی


• An indigenous cold kit of Ubiquicidin, UBI (29–41), for preparation of 99mTc-UBI (29-41) for infection imaging was formulated.
• Simple ITLC method to calculate yield of 99mTc-UBI (29-41) complex was established.
• Consistent batch production of UBI kit with acceptable criteria was demonstrated.

The aim of this study was to formulate an indigenous cold kit of Ubiquicidin, UBI (29-41), for easy preparation of 99mTc-UBI (29-41) to be used as an infection imaging agent. A two component kit with the peptide and SnCl2 as vial 1 and optimum amount of NaOH as vial 2 was successfully formulated as seen from the consistent radiochemical and pharmaceutical purity of the product over six consecutive batches of kits. The utility of the kit could be demonstrated through in-vitro and in vivo specificity of 99mTc-UBI (29-41).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 107, January 2016, Pages 8–12
نویسندگان
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