کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1875677 | 1532090 | 2016 | 5 صفحه PDF | دانلود رایگان |
• An indigenous cold kit of Ubiquicidin, UBI (29–41), for preparation of 99mTc-UBI (29-41) for infection imaging was formulated.
• Simple ITLC method to calculate yield of 99mTc-UBI (29-41) complex was established.
• Consistent batch production of UBI kit with acceptable criteria was demonstrated.
The aim of this study was to formulate an indigenous cold kit of Ubiquicidin, UBI (29-41), for easy preparation of 99mTc-UBI (29-41) to be used as an infection imaging agent. A two component kit with the peptide and SnCl2 as vial 1 and optimum amount of NaOH as vial 2 was successfully formulated as seen from the consistent radiochemical and pharmaceutical purity of the product over six consecutive batches of kits. The utility of the kit could be demonstrated through in-vitro and in vivo specificity of 99mTc-UBI (29-41).
Journal: Applied Radiation and Isotopes - Volume 107, January 2016, Pages 8–12