Semi-automated production of 89Zr-oxalate/89Zr-chloride and the potential of 89Zr-chloride in radiopharmaceutical compounding

Interest in using 89Zr is rapidly increasing for immuno-PET applications due to its unique characteristics and increased availability. The focus of this study was to develop an optimized semi-automated methodology for producing 89Zr-oxalate/89Zr-chloride, and evaluate the potential application of 89Zr-chloride for radiopharmaceutical compounding. The data presented herein will be useful for the production of 89Zr-labeled radiopharmaceuticals and their compliance with regulatory issues for both preclinical and clinical use.