Nine-year interval recurrence after treatment of boron neutron capture therapy in a patient with glioblastoma: A case report

• A patients with glioblastoma mutliforme could be alive more than 9 years after BNCT.
• BNCT may be effective for the local control of GBM.
• The following TMZ and conventional radiation may be effective for prevention of CSF dissemination.

Boron neutron capture therapy (BNCT) has been reported to be effective in the patients with glioblastoma multiforme (GBM). Median survival time (MST) of GBM patients treated with BNCT is approximately two years. GBM patients surviving 2 or 3 years are considered long-term survivors. In general, most recurrences are local and dissemination is rare. We report an unusual patient with three recurrences; the first and the second recurrences were local, and the third recurrence was dissemination nine years after BNCT.