Estimated human absorbed dose of 177Lu-BPAMD based on mice data: Comparison with 177Lu-EDTMP

In this work, the absorbed dose of human organs for 177Lu-BPAMD was evaluated based on biodistribution studies into the Syrian mice by RADAR method and was compared with 177Lu-EDTMP as the only clinically used Lu-177 bone-seeking agent. The highest absorbed dose for both 177Lu-BPAMD and 177Lu-EDTMP is observed on the bone surface with 8.007 and 4.802 mSv/MBq. Generally, 177Lu-BPAMD has considerable characteristics compared with 177Lu-EDTMP and can be considered as a promising agent for the bone pain palliation therapy.