82Sr purification procedure using Chelex-100 resin

82Rb is a positron-emitting radionuclide widely used in nuclear cardiology. One great advantage is its availability through a generator loaded with 82Sr. 82Sr can be produced in a high energy cyclotron by irradiating rubidium chloride target with proton beam. In this paper, we present an extensive study (elution profiles, effect of the elution flow rate) on the use of Chelex-100 resin and ammonia buffer. No significant effect of flow rate was evidenced between 1 and 10 mL/min leading us to propose a purification process which can be easily automated.

► The final solution of 82Sr can be used for loading generator.
► The flow rate can be increased up to 10 mL/min.
► The purification process can be also automated.