Evaluation of rib microstructure in Wistar rats using SR-μCT after radiation therapy simulation for breast cancer

A better understanding of biological interactions that occur after exposure to photon radiation is needed in order to optimize therapeutic regimens and facilitate development and strategies that decrease radiation-induced side effects in humans. In this work, ribs of Wistar rat submitted to radiotherapy simulation were imaged using synchrotron radiation computed microtomography at Elettra Synchrotron Laboratory in Trieste, Italy. Histomorphometric parameters were calculated directly from the 3D microtomographic images and showed significant differences between irradiated and non-irradiated groups.

► In this work we used SR-μCT to evaluate ribs of Wistar rats.
► Rats were submitted to radiation therapy for breast cancer.
► Results showed alterations in histomorphometric indices.