کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1876305 | 1041998 | 2012 | 9 صفحه PDF | دانلود رایگان |
Imaging of TSPO 18 kDa with PET is more and more considered as a relevant biomarker of inflammation in numerous diseases. Development of new radiotracers for TSPO 18 kDa has seen acceleration in the last years and the challenge today is to make available large amounts of such a radiotracer in compliance with GMP standards for application in humans. We present in this technical note automated productions of [18F]DPA-714, [18F]PBR111 and [18F]FEDAA1106, three promising radiotracers for TSPO 18 kDa imaging, using a TRACERlab FX-FN synthesizer. This note also includes the quality control data of the validation batches for the manufacturing qualification of clinical production of [18F]DPA-714.
► Protein TSPO 18 kDa is recognized as a biomarker of inflammation involved in many diseases.
► Radiotracers targeting TSPO prepared in compliance with GMPs are mandatory as new imaging tools.
► An automated radiosynthesis of promising radiotracers and full QC have been implemented.
Journal: Applied Radiation and Isotopes - Volume 70, Issue 3, March 2012, Pages 489–497