کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1876329 | 1041999 | 2012 | 9 صفحه PDF | دانلود رایگان |
[11C]DAA1106 was prepared by O-[11C]methylation of DAA1123 with [11C]CH3OTf and NaH in CH3CN at 80 °C and isolated by HPLC combined with SPE purification in 60–70% decay corrected radiochemical yield. [18F]FEDAA1106 was synthesized by the nucleophilic substitution of tosyloxy-FEDAA1106 in DMSO with K[18F]F/Kryptofix 2.2.2 at 140 °C and isolated by HPLC combined with SPE purification in 30–60% decay corrected radiochemical yield. The specific activity for [11C]DAA1106 and [18F]FEDAA1106 was 370–740 GBq/μmol and 37–222 GBq/μmol at EOB, respectively.
► Fully automated syntheses of [11C]DAA1106 and [18F]FEDAA1106 have been developed.
► Simplified solid-phase extraction (SPE) method was employed in radiosynthesis.
► Syntheses of DAA1106, FEDAA1106 and their precursors have been improved.
Journal: Applied Radiation and Isotopes - Volume 70, Issue 6, June 2012, Pages 965–973