Effect of time period after boric acid injection on 10B absorption in different regions of adult male rat's brain

Distribution of 10B in different regions of rat normal brain was studied. Two groups were chosen as control and trial. Trial group received 2 ml of neutral boron compound. 2, 4 and 6  h after the injection brain removed, coronal sections of forebrain, midbrain and hindbrain were sandwiched between two pieces of polycarbonate. Autoradiography plots of 10B distribution showed significant differences in three regions with the highest 10B concentration in the forebrain during 4 h after injection.

► Normal tissue tolerance is very important in BNCT.
► This study has been done to determine 10B distribution in three anatomical regions of rat normal brain.
► These specific regions of brain have not been studied in previous BNCT projects.
► We found significant differences in 10B distribution between these three regions.
► In different time periods after neutral boron compound injection, there has been a significant difference in boron absorption.