کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1876362 | 1042004 | 2012 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Automated preparation of the dopamine D2/3 receptor agonist ligand [11C]-(+)-PHNO for human PET imaging studies Automated preparation of the dopamine D2/3 receptor agonist ligand [11C]-(+)-PHNO for human PET imaging studies](/preview/png/1876362.png)
Carbon-11 labelled (+)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol ([11C]-(+)-PHNO) is used as a high-affinity state, dopamine D2/3 receptor ligand in clinical PET studies. To facilitate its use, robust, rapid, efficient and GMP compliant methods are required for the manufacturing and QC testing processes. Additionally, to allow for full quantification of the resulting signal in the CNS, a reliable method is required to establish the parent plasma concentration over the course of the scan. This paper provides high-quality methods to support clinical application of [11C]-(+)-PHNO.
► Fully automated synthesis of [11C]-(+)-PHNO.
► Rapid multi-step synthesis and QC analysis.
► Reproducible synthesis process typically yielding more than 3 GBq of [11C]-(+)-PHNO.
► Very low failure rate.
Journal: Applied Radiation and Isotopes - Volume 70, Issue 2, February 2012, Pages 380–387