کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1876433 | 1042009 | 2011 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Fully automated synthesis of the M1 receptor agonist [11C]GSK1034702 for clinical use on an Eckert & Ziegler Modular Lab system Fully automated synthesis of the M1 receptor agonist [11C]GSK1034702 for clinical use on an Eckert & Ziegler Modular Lab system](/preview/png/1876433.png)
A fully automated and GMP compatible synthesis has been developed to reliably label the M1 receptor agonist GSK1034702 with carbon-11. Stille reaction of the trimethylstannyl precursor with [11C]methyl iodide afforded [11C]GSK1034702 in an estimated 10±3% decay corrected yield. This method utilises the commercially available modular laboratory equipment and provides high purity [11C]GSK1034702 in a formulation suitable for human use.
► Preparation of [11C]GSK1034702 through a Stille cross-coupling reaction.
► Provision of the applicability of commercially available modules for the synthesis of non-standard PET tracers.
► Defining specification for heavy metals content in final dose product.
► Presenting results from validation of manufacturing process.
Journal: Applied Radiation and Isotopes - Volume 69, Issue 10, October 2011, Pages 1390–1394