کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1876433 1042009 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fully automated synthesis of the M1 receptor agonist [11C]GSK1034702 for clinical use on an Eckert & Ziegler Modular Lab system
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
Fully automated synthesis of the M1 receptor agonist [11C]GSK1034702 for clinical use on an Eckert & Ziegler Modular Lab system
چکیده انگلیسی

A fully automated and GMP compatible synthesis has been developed to reliably label the M1 receptor agonist GSK1034702 with carbon-11. Stille reaction of the trimethylstannyl precursor with [11C]methyl iodide afforded [11C]GSK1034702 in an estimated 10±3% decay corrected yield. This method utilises the commercially available modular laboratory equipment and provides high purity [11C]GSK1034702 in a formulation suitable for human use.


► Preparation of [11C]GSK1034702 through a Stille cross-coupling reaction.
► Provision of the applicability of commercially available modules for the synthesis of non-standard PET tracers.
► Defining specification for heavy metals content in final dose product.
► Presenting results from validation of manufacturing process.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 69, Issue 10, October 2011, Pages 1390–1394
نویسندگان
, , ,