Questioning the value of 99mTc-HYNIC-annexin V based response monitoring after docetaxel treatment in a mouse model for hereditary breast cancer

Annexin V imaging is suggested to provide a good indication of cancer treatment efficacy. To study the accuracy of 99mTc-AnxV imaging, we monitored chemo-sensitive and chemo-resistant tumors in a mouse breast cancer model after treatment with docetaxel. Sensitive tumors showed a slight peak in 99mTc-AnxV uptake one day post-treatment, while uptake in resistant tumors remained constant. In contrast to immunohistochemical analysis, 99mTc-AnxV imaging could not be used to predict tumor response, due to large variation between animals.