کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1876577 1042022 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Parameters optimization defined by statistical analysis for cysteine–dextran radiolabeling with technetium tricarbonyl core
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
Parameters optimization defined by statistical analysis for cysteine–dextran radiolabeling with technetium tricarbonyl core
چکیده انگلیسی

The objective of this study was the development of a statistical approach for radiolabeling optimization of cysteine–dextran conjugates with Tc-99m tricarbonyl core. This strategy has been applied to the labeling of 2-propylene–S-cysteine–dextran in the attempt to prepare a new class of tracers for sentinel lymph node detection, and can be extended to other radiopharmaceuticals for different targets. The statistical routine was based on three-level factorial design. Best labeling conditions were achieved. The specific activity reached was 5 MBq/μg.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 69, Issue 4, April 2011, Pages 663–669
نویسندگان
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