کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1876577 | 1042022 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Parameters optimization defined by statistical analysis for cysteine–dextran radiolabeling with technetium tricarbonyl core
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The objective of this study was the development of a statistical approach for radiolabeling optimization of cysteine–dextran conjugates with Tc-99m tricarbonyl core. This strategy has been applied to the labeling of 2-propylene–S-cysteine–dextran in the attempt to prepare a new class of tracers for sentinel lymph node detection, and can be extended to other radiopharmaceuticals for different targets. The statistical routine was based on three-level factorial design. Best labeling conditions were achieved. The specific activity reached was 5 MBq/μg.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 69, Issue 4, April 2011, Pages 663–669
Journal: Applied Radiation and Isotopes - Volume 69, Issue 4, April 2011, Pages 663–669
نویسندگان
Eutimio Gustavo Fernández Núñez, Bluma Linkowski Faintuch, Rodrigo Teodoro, Danielle Pereira Wiecek, Natanael Gomes da Silva, Minas Papadopoulos, Maria Pelecanou, Ioannis Pirmettis, Renato Santos de Oliveira Filho, Adriano Duatti, Roberto Pasqualini,