کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1876591 | 1042024 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Automated production of copper radioisotopes and preparation of high specific activity [64Cu]Cu-ATSM for PET studies
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موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Automated production of copper radioisotopes and preparation of high specific activity [64Cu]Cu-ATSM for PET studies Automated production of copper radioisotopes and preparation of high specific activity [64Cu]Cu-ATSM for PET studies](/preview/png/1876591.png)
چکیده انگلیسی
60Cu and 64Cu are useful radioisotopes for positron emission tomography (PET) radiopharmaceuticals and may be used for the preparation of promising agents for diagnosis and radiotherapy. In this study, the production and purification of 60/64Cu starting from 60/64Ni using a new automated system, namely Alceo, is described. A dynamic process for electrodeposition and dissolution of 60/64Ni/60/64Cu was developed. Preliminary production yields of 60Cu and 64Cu were 400 and 300 mCi, respectively. 64Cu was used to radiolabel the hypoxia detection tracer ATSM with a specific activity of 2.2±1.3 Ci/μmol.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 68, Issue 1, January 2010, Pages 5–13
Journal: Applied Radiation and Isotopes - Volume 68, Issue 1, January 2010, Pages 5–13
نویسندگان
Mario Matarrese, Paolo Bedeschi, Roberto Scardaoni, Francesco Sudati, Annarita Savi, Annalisa Pepe, Valeria Masiello, Sergio Todde, Luigi Gianolli, Cristina Messa, Ferruccio Fazio,