کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1876607 | 1042024 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and biodistribution of a novel 99mTc nitrido dithiocarbamate complex containing aromatic group for cerebral imaging
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موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and biodistribution of a novel 99mTc nitrido dithiocarbamate complex containing aromatic group for cerebral imaging Synthesis and biodistribution of a novel 99mTc nitrido dithiocarbamate complex containing aromatic group for cerebral imaging](/preview/png/1876607.png)
چکیده انگلیسی
In the present study, the N-benzyl dithiocarbamate (BZDTC) was synthesized and radiolabeled with [99mTcN]2+ intermediate to form the bis(N-benzyl dithiocarbamato) nitrido technetium-99m complex [99mTcN(BZDTC)2]. The radiochemical purity of the complex was over 90% by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC). It was stable over 6Â h at room temperature. The partition coefficient and electrophoresis results indicated that this complex was lipophilic and neutral. Biodistribution in mice showed that the complex accumulated in the brain with high uptake. The brain uptake (ID%/g) was 1.87, 1.21 and 0.85 and the brain/blood ratio was 0.75, 1.55 and 1.12 at 5, 30 and 60Â min post-injection, respectively. These results suggest that this complex could be a potential brain perfusion imaging agent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 68, Issue 1, January 2010, Pages 101-104
Journal: Applied Radiation and Isotopes - Volume 68, Issue 1, January 2010, Pages 101-104
نویسندگان
JunBo Zhang, Xiao Lin, Jialei Ren, Jing Liu, XueBin Wang,