A possible in vivo generator 103Pd/103mRh—Recoil considerations

The use of Auger emitters as potential radiopharmaceuticals is increasingly investigated. One such radionuclide of interest is 103mRh. This can be produced from 103Ru or from 103Pd in an in vivo generator. A potential problem with this concept is the recoil of the 103mRh out of the carrier molecule and even out of the target cell. In order to determine whether this would happen in the 103Pd/103mRh case calculations were done to prove that this does not happen. From theoretical considerations it seems that the 103Pd/103mRh in vivo generator system would be possible.