کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1877129 | 1042047 | 2008 | 7 صفحه PDF | دانلود رایگان |
Carbon-11 labeled cyclofenil derivatives, [11C]methyl-2-{4-[bis(4-hydroxyphenyl)methylene]cyclohexyl}acetate ([11C]16a), [11C]methyl-4-[bis(4-hydroxyphenyl)methylene]cyclohexanecarboxylate ([11C]16b), [11C]methyl-2-{3-[bis(4-hydroxyphenyl)methylene]cyclohexyl}acetate ([11C]18a), and [11C]methyl-3-[bis(4-hydroxyphenyl)methylene]cyclohexanecarboxylate ([11C]18b), have been synthesized as new potential PET agents for imaging breast cancer estrogen receptors. The target tracers were prepared by O-[11C]methylation of their corresponding precursors using [11C]CH3OTf and isolated by a simplified SPE purification procedure in 35–50% radiochemical yields decay corrected to EOB, 15–20 min overall synthesis time, and 74–111 GBq/μmol specific activity at EOS.
Journal: Applied Radiation and Isotopes - Volume 66, Issue 4, April 2008, Pages 523–529