کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1877364 | 1042071 | 2007 | 5 صفحه PDF | دانلود رایگان |
A novel fluorine-18 labeled amine fluorocyanoborane derivative was synthesized from the bromo-derivative precursor in 22% radiochemical yield. The [18F] labeling was accomplished by a semiautomatic method that is based on the synthesis of Ag18F from Ag2CO3 and H18F in a platinum dish followed by sonication of the bromo-precursor with Ag18F in dry benzene to produce [18F] labeled amine fluorocyanoborane which was used with no further purification. A total of 50 μCi of the [18F] labeled amine fluorocyanoborane was injected into normal, female Sprague–Dawley rats (250–300 g) via the tail vein and monitored by Positron emission tomography (PET)/CT to detect its biodistribution in the rat body. The images showed an uptake of this compound in the bones of rats.
Journal: Applied Radiation and Isotopes - Volume 65, Issue 2, February 2007, Pages 204–208