کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1877507 | 1532096 | 2015 | 5 صفحه PDF | دانلود رایگان |
• The processing method is scalable for optimized purification of Ge-68 and Zn-65.
• The purified Ge-68 meet DOE specifications and recoveries were >90%.
• The processing methods were used to purify ~2.5 Ci of Ge-68 at BNL in 2012–2013.
• New processing methods minimize potential of Ge-68/Ga-68 volatility.
• The processing methods do not use toxic organic solvents and are FDA compliant.
Germanium-68 (Ge-68) is produced by proton irradiation of a gallium metal target, purified by organic extraction and used in a medical isotope generator to produce Gallium-68 PET imaging agents. The purpose of this work was to implement a production scale separation of Ge-68 and Zn-65 that does not use organic solvents and uses a limited number of columns. The current separation approach was modified to use AG1 resin and/or Sephadex© G25 with zinc spikes to purify Ge-68 with near quantitative recovery. The purified Ge-68 meets DOE specifications. Methods utilizing zinc spikes resulted in the purist Ge-68 produced at Brookhaven National Lab with no other impurities by ICP-OES. During process optimization approximately 2.5 Ci of Ge-68 was purified utilizing the different processing methods, and the material was sold to the Nuclear Medicine community between 2012–2013.
Journal: Applied Radiation and Isotopes - Volume 101, July 2015, Pages 60–64