Automation synthesis modules review

The introduction of 68Ga labelled tracers has changed the diagnostic approach to neuroendocrine tumours and the availability of a reliable, long-lived 68Ge/68Ga generator has been at the bases of the development of 68Ga radiopharmacy. The huge increase in clinical demand, the impact of regulatory issues and a careful radioprotection of the operators have boosted for extensive automation of the production process. The development of automated systems for 68Ga radiochemistry, different engineering and software strategies and post-processing of the eluate were discussed along with impact of automation with regulations.

► Generators availability and robust chemistry boosted for the huge diffusion of 68Ga radiopharmaceuticals.
► Different technological approaches for 68Ga radiopharmaceuticals will be discussed.
► Generator eluate post processing and evolution to cassette based systems were the major issues in automation.
► Impact of regulations on the technological development will be also considered.