99mTc-labeled-1-thio-β-d-glucose as a new tool to temporomandibular joint inflammatory disorders diagnosis

AimThe aim of this study was to evaluate early detection of temporomandibular joint (TMJ) inflammatory changes based on 1-thio-β-d-glucose radiolabeled with technetium-99m.MethodThe method applied a TMJ inflammation model in rats followed by radiopharmaceutical synthesis, intravenous administration of 99mTc-1-TG and kinetic scintigraphy imaging.ResultsResults show a significant difference of 99mTc-1-TG uptake between inflamed TMJ and the control joint. The biodistribution of 99mTc-1-TG by images showed the kidneys’ excretion.ConclusionAs conclusion, 99mTc-1-TG is a helpful tool in TMJ inflammatory process detection.