کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1878081 1042274 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
“Label and go” - A fast and easy radiolabelling method for pellets
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
“Label and go” - A fast and easy radiolabelling method for pellets
چکیده انگلیسی
For the development and process optimization of pharmaceutical equipment, it is important to investigate the underlying processes. Taking the fluidized bed technology as an example, the study of particle flow pattern and convection of the particles within the functional unity is essential for construction and process improvement. With positron emission particle tracking (PEPT) it is possible to study the real-time particle motion with radiolabelled particles. We established a fast and simple labelling technique with [18F]fluoride for pellets composed of Avicel and anion exchange resin. The uptake of activity ranged from 1.3% to 1.7% per mg and 8.6% to 16.3% per pellet. A specific binding of [18F]fluoride with increasing degree of anion exchange resin in the pellets could be observed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 68, Issue 3, March 2010, Pages 399-403
نویسندگان
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