کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1878092 | 1042274 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of carbon-11-labeled piperidine ring of N-[Ï-(6-methoxynaphthalen-1-yl)alkyl] derivatives as new selective PET Ï1 receptor probes
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Carbon-11-labeled piperidine ring of N-[Ï-(6-methoxynaphthalen-1-yl)alkyl] derivatives were first designed and synthesized as new selective PET Ï1 receptor probes. The target tracers were prepared by O-[11C]methylation of their corresponding phenolic hydroxyl precursors using [11C]CH3OTf under basic conditions and isolated by a simplified SPE method in 40-50% radiochemical yields based on [11C]CO2 and decay corrected to EOB. The overall synthesis time from EOB was 15-20 min, the radiochemical purity was >99%, and the specific activity at EOS was 111-185 GBq/μmol.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 68, Issue 3, March 2010, Pages 459-465
Journal: Applied Radiation and Isotopes - Volume 68, Issue 3, March 2010, Pages 459-465
نویسندگان
Mingzhang Gao, Min Wang, Gary D. Hutchins, Qi-Huang Zheng,