کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1878168 | 1532128 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The robotic radiosynthesis of 5-[18F]fluoro-2â²-deoxyuridine and its biological characterization
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The robotic radiosynthesis of 5-[18F]fluoro-2â²-deoxyuridine and its biological characterization The robotic radiosynthesis of 5-[18F]fluoro-2â²-deoxyuridine and its biological characterization](/preview/png/1878168.png)
چکیده انگلیسی
5-[18F]fluoro-2â²-deoxyuridine ([18F]FUdR) was synthesized using a robotic system as a proliferation probe for PET. [18F]FUdR was prepared via radiofluorodestannylation reaction from its organotin precursor. Biodistribution study and microPET imaging of [18F]FUdR in NG4TL4 sarcoma-bearing FVB/n mice were performed. The tumor-to-blood and tumor-to-muscle ratio increased steadily from 15 (1.81 and 3.42) to 120Â min (9.10 and 11.9) post injection. The dynamic microPET imaging demonstrates remarkable radioactivity retention in the tumor, which is consistent with the results of biodistribution study.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 67, Issues 7â8, JulyâAugust 2009, Pages 1355-1361
Journal: Applied Radiation and Isotopes - Volume 67, Issues 7â8, JulyâAugust 2009, Pages 1355-1361
نویسندگان
C.W. Chang, Y.Y. Lin, C.J. Peng, M. Lin, R.S. Liu, S.J. Wang, W.J. Lin, H.E. Wang,