Fully automated radiosynthesis of both enantiomers of [18F]Flubatine under GMP conditions for human application

• A fully automatized radiosynthesis of Flubatine under GMP conditions is reported.
• Radiochemical yields of 30% in 40 min were achieved in more than 70 syntheses.
• Specific activitiy of 3000 GBq/μmol and radiochemical purity of more than 97% were achieved.

A fully automatized radiosynthesis of (+)- and (−)-[18F]Flubatine ((+)- and (−)NCFHEB) by means of a commercially available synthesis module (TRACERlab FX FN) under GMP conditions is reported. Radiochemical yields of 30% within an overall synthesis time of 40 min were achieved in more than 70 individual syntheses. Specific activities were approximately 3000 GBq/μmol and radiochemical purity was determined to be at least 97%.