کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1879002 | 1042535 | 2012 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of [123I]ADAM, a serotonin transporter radiopharmaceutical, on pregnant Sprague–Dawley rats
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موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of [123I]ADAM, a serotonin transporter radiopharmaceutical, on pregnant Sprague–Dawley rats Effects of [123I]ADAM, a serotonin transporter radiopharmaceutical, on pregnant Sprague–Dawley rats](/preview/png/1879002.png)
چکیده انگلیسی
Serotonin transport abnormalities are implicated in neuropsychiatric disorders. [123I]ADAM ([123I]-2-([2-({dimethylamino}methyl)phenyl]thio)-5-iodophenylamine) is a novel radiotracer that targets serotonin transporters.We assessed the toxicity of [123I]ADAM (18.5 MBq) administered in early- and late-phases (8 and 14 day postfertilization, respectively) of pregnancy. The mortality, clinical status, and gross necropsy were measured in pregnant rats, and the fertility index was measured in rat offspring (weight, clinical observations). We found no dosing-related clinical signs.In conclusion, [123I]ADAM was not toxic in an animal pregnancy model.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 70, Issue 11, November 2012, Pages 2646–2651
Journal: Applied Radiation and Isotopes - Volume 70, Issue 11, November 2012, Pages 2646–2651
نویسندگان
K.W. Chang, M.C. Lin, S.Y. Lee, H.Y. Chen, C.C. Chen, Y.K. Fu,