Reusable electrochemical cell for rapid separation of [18F]fluoride from [18O]water for flow-through synthesis of 18F-labeled tracers

► Electrochemical cells can rapidly separate [18F]fluoride from [18O]water. ► Use of metal electrodes enables high speed, efficiency and reusability. ► Adsorption interactions on various metal surfaces were studied with XPS. ► Cell was coupled to a flow reactor to automatically synthesize [18F]FDG in <15 min. ► A multi-human dose of 5.92 GBq of [18F]FDG was synthesized.