کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1879766 | 1042592 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and evaluation of fluorine-18 labelled compounds for imaging of bacterial infections with pet
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موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
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چکیده انگلیسی
Syntheses of no carrier added (n.c.a.) 6-fluoro-1,4-dihydro-1-cyclopropyl-4-oxo-7-[4-[18F]fluoro-phenacyl-1-piperacinyl]-chinolincarboxylic acid ([18F]COPCA) and n.c.a. 4-[18F]fluoro-benzoyl-ubiquicidin 29-41 ([18F]UBI 29-41) are described. [18F]COPCA was synthesised within 120 min with a radiochemical yield of 9–12%. [18F]UBI 29-41 was synthesised within 150 min with a radiochemical yield of 15–20%. Both compounds had a specific activity of more than 35 GBq/μ mol. The biological activity was verified by measuring its binding to Staphylococcus aureus bacteria. Specific binding was found for [18F]UBI 29-41 (12–17%), whereas no specific binding for [18F]COPCA was found.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 64, Issue 7, July 2006, Pages 802–807
Journal: Applied Radiation and Isotopes - Volume 64, Issue 7, July 2006, Pages 802–807
نویسندگان
S. Zijlstra, J. Gunawan, C. Freytag, W. Burchert,