کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1879932 | 1042605 | 2006 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Analysis of 18F-labelled synthesis products on TLC plates: Comparison of radioactivity scanning, film autoradiography, and a phosphoimaging technique Analysis of 18F-labelled synthesis products on TLC plates: Comparison of radioactivity scanning, film autoradiography, and a phosphoimaging technique](/preview/png/1879932.png)
We compared radioactivity scanning, film autoradiography, and digital photostimulated luminescence (PSL) autoradiography (phosphoimaging technique) in detection of radioactivity on thin-layer chromatography (TLC) plates. TLC combined with radioactivity detection is rapid, simple, and relatively flexible. Here, 18F-labelled synthesis products were analyzed by TLC and the radioactivity distribution on the plates determined using the three techniques. Radioactivity scanning is appropriate only with good chromatographic resolution and previously validated scanning parameters. Film autoradiography exhibits poor linearity if radioactivity varies greatly. PSL provides high sensitivity and resolution and superior linearity compared with the other methods.
Journal: Applied Radiation and Isotopes - Volume 64, Issue 9, September 2006, Pages 1043–1047