کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1882795 1043261 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Treatment of statin compounds by advanced oxidation processes: Kinetic considerations and destruction mechanisms
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
Treatment of statin compounds by advanced oxidation processes: Kinetic considerations and destruction mechanisms
چکیده انگلیسی

This study examined the use of advanced oxidation/reduction processes (AO/RPs) for the destruction of cholesterol lowering statin pharmaceuticals. AO/RPs which utilize the oxidizing hydroxyl radical (OH) and reducing aqueous electron (e−aq), to degrade chemical contaminants are alternatives to traditional water treatment methods, and are alternatives as water reuse becomes more generally implemented. Four major statin pharmaceuticals, fluvastatin, lovastatin, pravastatin and simvastatin, were studied, and the absolute bimolecular reaction rate constants with OH determined, (6.96±0.16)×109, (2.92±0.06)×109, (4.16±0.13)×109, and (3.13±0.15)×109 M−1 s−1, and for e−aq (2.31±0.06)×109, (0.45±0.01)×109, (1.26±0.01)×109, and (0.69±0.02)×109 M−1 s−1, respectively. To provide additional information on the radicals formed upon oxidation, transient spectra were measured and the overall reaction efficiency determined. Radical-based destruction mechanisms for destruction of the statins are proposed based on the LC-MS determination of the stable reaction by-products formed using 137Cs γ-irradiation of statin solutions. Knowing the reaction rates, reaction efficiencies and destruction mechanisms of these compounds is essential for the consideration of the use of advanced oxidation/reduction processes for the destruction of statins in aqueous systems.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiation Physics and Chemistry - Volume 80, Issue 3, March 2011, Pages 453–461
نویسندگان
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