کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1883599 1043300 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gold nanoparticles enhance the X-ray-induced degradation of human centrin 2 protein
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
Gold nanoparticles enhance the X-ray-induced degradation of human centrin 2 protein
چکیده انگلیسی

In the war against cancer, radiotherapy is a prominent tool but counterbalanced by the fact that it also induces damages in healthy tissues. Nanotechnologies could open a new possibility to decrease these side effects. In particular, gold nanoparticles (GNPs) could be used as radio-sensitizers. As the role of proteins in the processes leading to cell death cannot be neglected, their radio-sensitization by GNPs is of great interest. This is particularly true in the case of the human centrin 2 protein, which has been proposed to be involved in DNA repair processes. To investigate this effect, we quantified for the first time the degradation of this protein in a gold colloidal solution when submitted to X-rays. We showed that the X-ray-induced degradation of the human centrin 2 protein is enhanced 1.5-fold in the presence of GNPs, even though no covalent bond exists between protein and GNPs. Among the conditions tested, the maximum enhancement was found with the higher GNP:protein ratio of 2×10−4 and with the higher X-ray energy of 49 keV.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiation Physics and Chemistry - Volume 78, Issue 3, March 2009, Pages 177–183
نویسندگان
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