کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1886683 | 1043544 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
LET dependence of the formation of oxidative damage 8-hydroxy-2′-deoxyguanosine (8-OHdG) in 2′-deoxyguanosine aqueous solution irradiated with heavy ions
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: LET dependence of the formation of oxidative damage 8-hydroxy-2′-deoxyguanosine (8-OHdG) in 2′-deoxyguanosine aqueous solution irradiated with heavy ions LET dependence of the formation of oxidative damage 8-hydroxy-2′-deoxyguanosine (8-OHdG) in 2′-deoxyguanosine aqueous solution irradiated with heavy ions](/preview/png/1886683.png)
چکیده انگلیسی
To evaluate the contribution of indirect action mediated by OH radicals in biological effects of high LET radiations, we examined the production of 8-hydroxy-2′-deoxyguanosine (8-OHdG) in 2′-deoxyguanosine aqueous solution using various ion species with an LET range from 20 to 300 keV/μm. The 8-OHdG yield decreased with increasing LET. In the hypoxic irradiation condition, the yield showed constant or rather increasing tendency above about 100 keV/μm, which is consistent with an oxygen-in-the-track hypothesis to explain the diminishment of oxygen effect.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiation Physics and Chemistry - Volume 78, Issue 12, December 2009, Pages 1207–1210
Journal: Radiation Physics and Chemistry - Volume 78, Issue 12, December 2009, Pages 1207–1210
نویسندگان
Ryoichi Hirayama, Yoshiya Furusawa, Chieko Murayama, Yosuke Kusano, Atsushi Ito,