کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1886683 1043544 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
LET dependence of the formation of oxidative damage 8-hydroxy-2′-deoxyguanosine (8-OHdG) in 2′-deoxyguanosine aqueous solution irradiated with heavy ions
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
LET dependence of the formation of oxidative damage 8-hydroxy-2′-deoxyguanosine (8-OHdG) in 2′-deoxyguanosine aqueous solution irradiated with heavy ions
چکیده انگلیسی

To evaluate the contribution of indirect action mediated by OH radicals in biological effects of high LET radiations, we examined the production of 8-hydroxy-2′-deoxyguanosine (8-OHdG) in 2′-deoxyguanosine aqueous solution using various ion species with an LET range from 20 to 300 keV/μm. The 8-OHdG yield decreased with increasing LET. In the hypoxic irradiation condition, the yield showed constant or rather increasing tendency above about 100 keV/μm, which is consistent with an oxygen-in-the-track hypothesis to explain the diminishment of oxygen effect.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiation Physics and Chemistry - Volume 78, Issue 12, December 2009, Pages 1207–1210
نویسندگان
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