کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1887453 | 1533547 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Radiation sterilization of antibiotic liposome formulations: A case study
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
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چکیده انگلیسی
New liposome formulations for antimycobacterial purpose are under development in Portugal. The drug must be submitted to a sterilization process. In order to find out if gamma radiation could be applied, microbiological and chemical studies were developed based on ISO standards. The bioburden was determined, the main critical points of line production were detected and the sterilization dose was determined based on a chart control for bioburden. A preliminary maximum acceptable dose for product was found out based on the main functional parameters.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiation Physics and Chemistry - Volume 76, Issues 8â9, AugustâSeptember 2007, Pages 1542-1546
Journal: Radiation Physics and Chemistry - Volume 76, Issues 8â9, AugustâSeptember 2007, Pages 1542-1546
نویسندگان
M.L. Botelho, S. Cabo Verde, L. Alves, A. Belchior, J. Reymão, S. Trabulo, M.M. Gaspar, M.E.M Cruz, S. Simões,