کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1891232 | 1533521 | 2014 | 10 صفحه PDF | دانلود رایگان |
• Swelling of hydrogels decreased with increase in radiation dose.
• Swelling increased with increase in hydrophillicity of hydrogels.
• Slow release of indinavir from sulfated hydrogels.
• Drug release followed non-Fickian mechanism.
In the present work, in order to improve the drug release profile of indinavir sulfate, a potent inhibitor of HIV protease, controlled drug delivery systems in the form of hydrogels have been designed by a radiation graft polymerization method. These hydrogels have been prepared by using dietary fiber psyllium and binary monomers mixture of acrylamide (AAm) and 2-acrylamido-2-methylpropanesulfonic acid (AMPSA). These polymers have been characterized with cryo-SEMs, FTIR, XRD and swelling studies. The swelling of hydrogels has been determined in solution of different pH, temperature and [NaCl]. in vitro release studies of model drug indinavir sulfate in different pH have been carried out to determine the drug release mechanism. The release of dug occurred through non-Fickian mechanism.
Journal: Radiation Physics and Chemistry - Volume 103, October 2014, Pages 178–187