کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1906181 1534874 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intrinsic and extrinsic mortality reunited
ترجمه فارسی عنوان
مرگ و میر درونی و بیرونی دوباره متحد شده است
کلمات کلیدی
مرگ و میر درونی، مرگ و میر بیرونی، تقسیم مرگ و میر، سالخورده، تعامل ژن و محیط زیست
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی


• Intrinsic and extrinsic mortality are often partitioned.
• This classification is ill-defined and misleading.
• The risks of intrinsic and extrinsic mortality increase similarly over age.
• Genetic and environmental stressors interact to cause aging and death.
• This is of relevance for biomedical research, clinical practice and public health.

Intrinsic and extrinsic mortality are often separated in order to understand and measure aging. Intrinsic mortality is assumed to be a result of aging and to increase over age, whereas extrinsic mortality is assumed to be a result of environmental hazards and be constant over age. However, allegedly intrinsic and extrinsic mortality have an exponentially increasing age pattern in common. Theories of aging assert that a combination of intrinsic and extrinsic stressors underlies the increasing risk of death. Epidemiological and biological data support that the control of intrinsic as well as extrinsic stressors can alleviate the aging process. We argue that aging and death can be better explained by the interaction of intrinsic and extrinsic stressors than by classifying mortality itself as being either intrinsic or extrinsic. Recognition of the tight interaction between intrinsic and extrinsic stressors in the causation of aging leads to the recognition that aging is not inevitable, but malleable through the environment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 67, July 2015, Pages 48–53
نویسندگان
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