کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1906430 | 1046287 | 2011 | 5 صفحه PDF | دانلود رایگان |

We performed proteomic analysis of plasma proteins in Japanese semisuper centenarians (SSCs) (> 105 years) and young controls (20-39 years), and found that 18 protein spots were altered in the plasma of SSCs. From peptide mass fingerprinting following in-gel digestion, it was demonstrated that paraoxonase/arylesterase 1 (PON 1) and apolipoprotein E were decreased, while haptoglobin β-chain, α1-microglobulin, and clusterin precursor were increased in SSCs. Interestingly, proteins related to oxidative stress, PON1, haptoglobin, α1-microglobulin, and clusterin, were altered in SSCs. These results suggest that systemic redox regulation is important for the longevity of SSCs. Overall, proteomics analysis is a powerful technique to search for useful biomarkers for future studies in gerontology and to characterize the individual proteins associated with successful aging of SSCs.
Research highlights
► Four proteins associated with oxidative stress regulation, paraoxonase/arylesterase 1, haptoglobin, a1-microglobulin, and clusterin, were altered in Japanese semisuper centenarians (>105 years) (SSCs).
► Systemic redox regulation is important for the longevity of SSCs.
► Proteomics analysis is a powerful technique to search for useful biomarkers to study gerontology and to characterize individual proteins in the successful aging of SSCs.
Journal: Experimental Gerontology - Volume 46, Issue 1, January 2011, Pages 81–85