کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1906430 1046287 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Proteomic analysis of plasma proteins in Japanese semisuper centenarians
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Proteomic analysis of plasma proteins in Japanese semisuper centenarians
چکیده انگلیسی

We performed proteomic analysis of plasma proteins in Japanese semisuper centenarians (SSCs) (> 105 years) and young controls (20-39 years), and found that 18 protein spots were altered in the plasma of SSCs. From peptide mass fingerprinting following in-gel digestion, it was demonstrated that paraoxonase/arylesterase 1 (PON 1) and apolipoprotein E were decreased, while haptoglobin β-chain, α1-microglobulin, and clusterin precursor were increased in SSCs. Interestingly, proteins related to oxidative stress, PON1, haptoglobin, α1-microglobulin, and clusterin, were altered in SSCs. These results suggest that systemic redox regulation is important for the longevity of SSCs. Overall, proteomics analysis is a powerful technique to search for useful biomarkers for future studies in gerontology and to characterize the individual proteins associated with successful aging of SSCs.

Research highlights
► Four proteins associated with oxidative stress regulation, paraoxonase/arylesterase 1, haptoglobin, a1-microglobulin, and clusterin, were altered in Japanese semisuper centenarians (>105 years) (SSCs).
► Systemic redox regulation is important for the longevity of SSCs.
► Proteomics analysis is a powerful technique to search for useful biomarkers to study gerontology and to characterize individual proteins in the successful aging of SSCs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 46, Issue 1, January 2011, Pages 81–85
نویسندگان
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