کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1906593 1046300 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans
چکیده انگلیسی

Aging is a process of gradual functional decline leading to death. Reactive oxygen species (ROS) not only contribute to oxidative stress and cell damage that lead to aging but also serve as signaling molecules. Sestrins are evolutionarily conserved in all multicellular organisms and are required for regenerating hyperoxidized forms of peroxiredoxins and ROS clearance. However, whether sestrins regulate longevity in metazoans is still unclear. Here, we demonstrated that SESN-1, the only sestrin ortholog in Caenorhabditis elegans, is a positive regulator of lifespan. sesn-1 gene mutant worms had significantly shorter lifespans compared to wild-type animals, and overexpression of sesn-1 prolonged lifespan. Moreover, sesn-1 was found to play a key role in defense against several life stressors, including heat, hydrogen peroxide and the heavy metal copper; and sesn-1 mutants expressed higher levels of ROS and showed a decline in body muscle function. Surprisingly, loss of sesn-1 did not weaken the innate immune function of the worms. Together, these results suggest that SESN-1 is required for normal lifespan and its function in muscle cells prevents muscle degeneration over a lifetime.


► SESN-1 is a positive regulator of lifespan in C. elegans.
► Mutations in sesn-1 confer increased sensitivity to life stressors and oxidative stress.
► Homeostasis of reactive oxygen species (ROS) requires normal sesn-1 in C. elegans.
► sesn-1 is also required for maintenance of healthspan in C. elegans.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 48, Issue 3, March 2013, Pages 371–379
نویسندگان
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