Age-associated plasticity of α1-adrenoceptor-mediated tuning of T-cell development

► Ageing increases thymic NA level and α1-AR thymocyte surface density. ► α1-AR-mediated NA influence on T-cell development is altered in the involuted thymus. ► Ageing increases the basal α1-AR-mediated inhibitory influence of NA on thymopoiesis.