کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1907023 1534896 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cell intrinsic and extrinsic mechanisms of stem cell aging depend on telomere status
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Cell intrinsic and extrinsic mechanisms of stem cell aging depend on telomere status
چکیده انگلیسی

The function of adult stem cells declines during aging and chronic diseases. An understanding of the molecular mechanisms underlying these processes will help to identify targets for future therapies in order to improve regenerative reserve and organ maintenance. Telomere shortening represents a cell intrinsic mechanism inducing DNA damage in aging cells. Current studies in telomerase knockout mice have shown that telomere dysfunction induces cell intrinsic checkpoints and environmental alteration that limit stem cell function. While these phenotypes differ from wild-type mice with long telomere reserves, they appear to be relevant for human aging, which is associated with an accumulation of telomere dysfunction and DNA damage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 44, Issues 1–2, January–February 2009, Pages 75–82
نویسندگان
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