کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1907219 1046340 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CD95-mediated apoptosis in naïve, central and effector memory subsets of CD4+ and CD8+ T cells in aged humans
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
CD95-mediated apoptosis in naïve, central and effector memory subsets of CD4+ and CD8+ T cells in aged humans
چکیده انگلیسی

Aging is associated with a decrease in naïve (TN) and central memory (TCM), and an accumulation of effector memory (TEM and TEMRA) T cell subsets. Previously, we have demonstrated an increased sensitivity of TN and TCM CD4+ and CD8+ T cells in aging to TNF-α-induced apoptosis. In this investigation, we examined whether similar differential sensitivity is applicable to CD95-mediated apoptosis. We show that TN and TCM CD4+ and CD8+ T cells from aged subjects are significantly more sensitive to CD95-mediated apoptosis. Increased apoptosis is associated with increased activation of caspase-8 and caspase-3. Both caspase-8 and caspase-3 inhibitors blocked CD95-mediated apoptosis and activation of caspase-8 and caspase-3 in TN and TCM CD4+ and CD8+ T cells. No significant difference was observed in apoptosis or in activation of caspase-8 and caspase-3 in TEM and TEMRA CD4+ and CD8+ T cells between young and aged subjects; both populations were relatively and comparably resistant to CD95-mediated apoptosis and caspase activation. No correlation was observed between the sensitivity/resistance of any of the subsets of CD4+ or CD8+T cells to CD95-mediated apoptosis and the expression of CD95. Our data suggest that increased CD95-mediated apoptosis of TN and TCM CD8+ and CD4+ T cells may play a role in their decline in human aging.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 43, Issue 4, April 2008, Pages 266–274
نویسندگان
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